Hronična imobilizacija, društvena izolacija i oksidativni stres

piše: Zvonko Džokić

Uvodna napomena

Tekst koji sledi nije nova oda uspešnosti svetskog projekta „Covid 19“. Pomenuti projekat je još u toku i trenutno prisilno zaokuplja pažnju tekućom vakcinacijom genetski još uvek nejasnim sadržajima, uz svakodnevnu i do sada neviđeno brutalnu medijsku i političku presiju koja se sprovodi 24/7h na skoro svakog pojedinca na planeti Zemlji i u skoro svakoj postojećoj državi.

Cilj ovog teksta je da ukaže na do sada dokazane naučne činjenice, za razliku od onih naučno nedokazanih, a uporno prezentovanih na početku i u toku „pandemije Covid 19“ u vezi etiologije i patogeneze iste, o izrazito razarajućim efektima hroničnog stresa putem nametanja prisilnog  dugotrajnog fizičkog, psihičkog i društvenog ograničenja (propraćenog kod ljudi u tekućoj kampanji dodatnom dozom konstantnog i enormnog zastrašivanja) primenjenih na živim organizmima iz kruga sisara. Čovek, valjda, i dalje spada u žive i takve organizme…?!

Ostaje na vama da povežete naučno dokazane činjenice koje slede u celinu sa pomenutim u prethodna dva teksta: „Projekat Covid 19 ili završna faza napada na Eros“ i „Doprinos projekta Covid 19 ubrzanoj shizofrenizaciji društva“. To će vam pomoći da još bolje shvatite glavne ciljeve iza-kulisne igre, koja se u samo jednom delu odigrava preko tekućeg projekta. Naravno, celini dodati i razarajuće efekte koje čine mediji plasiranjem postistina i lažnih vesti, gubitak posla, ratne igre, migracije, digitalna i virtuelna realnost u sklopu taktike pretvaranja preživelih ostataka ljudi u formu koja je u nastajanju – „Human 2.0“. A sve to na kraju povežite sa bazičnim tekstovima o stresu i stresnim poremećajima, isto tako na ovom sajtu.

Zašto baš sa stresom? Idemo dalje…

Hronični imobilizacijski stres

Na njemu se svakodnevno radi ni manje ni više nego već oko pedesetak godina u eksprimetnima koji se izvode na laboratorijskim životinjama. Isto tako dugo vremena se prate efekti imobilizacijskog stresa i kod primata. Vršena su, naravno daleko od očiju javnosti, prisilnim i nasilnim metodama i nad ljudima, obično od strane specijalnih vojnih i paravojnih „eksperta“. Ali, pošto su to obično činili i čine zaposlenici nosioca vrhunskih „demokratskih“ režima i „izuzetnih“ država (koje su obično izuzete i od odgovornosti pred međunarodnim insitucijama koje sude o krivičnoj odogovornosti o zločinima protiv čovečnosti), ovakve informacije su nedostupne ostalima, a svako njihovo pominjanje je unapred etiketirano kao neka od „teorija zavere“ ili da takve informacije ugrožavaju njihovu „nacionalnu bezbednost“. Pa još mogu da nastradaju i oni koji ih otkrivaju, što nam je već viđeno i uteranim strahom od brutalne kazne prihvaćeno „kao normalno“.

Elem, sumirano iskustvo iz ovog područja ukazuje na jasne dugoročne efekte koje izaziva ograničavajući, prisilni pristup slobodi telesnog kretanja i opštenja. To su poremećaji koji se pojavljuju u mnogim sferama, kako u biološkoj i mentalnoj, tako i u socijalnoj.

Hronični imobilizacijski stres deluje na biološku matricu, odosno na neuro-endokrino-imunološku osovinu organizma, kao i na mentalno fukcionisanje i ponašajne modele jedinki na kojima se on primenjuje. Preko ovih sistema se sprovodi sistematsko razaranje prethodno uspostavljenih psihosomatskih i psihosocijalnih mehanizama i funkcija, stvaraju se uslovi trajnog disbalansa i modifikacije celokupne strukture organizma koji je podložen takvom „tretmanu“.

Tako, na ogromnom broju slučajeva utvrđeno je da na ponašajnom nivou dovodi najpre do porasta agresivnog ponašanja, sklonosti impulsivnosti, povišenoj borbenosti i zauzimanja neprijateljskog stava ka okolini. Zatim sledi razvoj fobičnih mehanizama „izbegavanja“, instaliranje uslovljenog modela osećanja bespomoćnosti, stvaranje podloge brzog „kondicioniranja“ strahom, dužeg trajanja reakcije „paralize“ pri novim stresnim provokacijama itd. Na mentalnom planu je primećena najpre institucionalizacija anksioznosti, a zatim razvoj depresivnosti i anhedonije, stanja nemotivisanosti, bezvoljnosti i doživljaja besmislenosti. Na metaboličkom planu su primećeni tipični poremećaji vezani za „burn out“ sindrom, u vidu poremećenog metabolizma lipida i šećera, porast enzima koji ukazuju na visceralne poremećaje. Na endokrinom planu je praćeno poremećajem hormona koji je tipičan u početku za akutni stres a zatim za hronični iscrpljujući stres, sa redukcijom kortizola u završnoj fazi itd. Na imunološkom planu  je, shodno prethodnom, primećen povećan broj autoimunih i malignih poremećaja, teže zarastanje rana, porast nivoa i uticaja faktora upale itd. Na citološkom i histološkom planu u već više od dve decenije ispitivanja dokazuju se poremećaji neuroplasiticiteta mozga, uz demijelinizaciju bele mase i atrofiju ćelija sive u bitnim delovima „limbičkom korteksa“, posebno u zonama hipokampusa i prednjeg (frontalnog) režnja…!!?

Socijalna distanca kao bitan projektni dodatak

Ograničavanje komunikacije sa prirodnom oklinom, posebno sprečavanje društvene komunikacije, je dodatak ovakvim projektima, sa ciljem pojačanja efekata „Horničnog imobilizacijskog stresa“ (CISChronic Immobilisation Stress). I sami znate da je glavna društvena kazna – kazna zatvorom, a to je praktično kazna imobilizacionim stresom. Međutim najteža forma ove legalne kazne za učinjeno zlodelo je stavljanje u „samicu“. A to je, dragi moji, dodatak u vidu „socijalne distance“ u neprirodnoj, zatvorenoj sredini. E, to je već „Izolacioni stres“ (ISIsolation Stress). Još ako je samica bez prozora, svetla i bilo kakve pozitivne informacije…

Na šta vas ovo podseća?!

Eksperimentalne životinje su istraživači stavljali u različite varijante uslovljavanja i situacije, primenom na različitom broju jedinki, promenom dužine trajanja, menjanja okolinskih uslova u periodu izolacije i dr. Došlo se do sada do velikog broja bitnih podataka i zaključaka.

Za nas, u skladu sa ovim tekstom, najbitniji su oni koji potvrđuju pojačanje i ubrzanje efekata koji  su opisani u prethodnom poglavlju. „Plus“ ovome je utvrđivanje nepobitnih dokaza da jedinke koje su podvrgnute „socijalnoj distanci“, odnosno usamljivanju u toku njihovog izlaganja CIS-u, stradaju od mnogo težih formi od onih koji su preživeli imobilizaciju i izolaciju u grupi sa drugima(!?). Efekti koji proizilaze iz ovoga su po težini minimum ravni efektima koji se javljaju nakon preživljavanja teških psihičkih trauma, odnosno „Ozbiljnih životnih stresova“ (SLSSerious Life Stress)!

Zašto je to tako?!

Nalaženje objašnjenja pomenutih poremećaja i traženje odgovora na prethodno pitanje vode ka jedinstvenom razlogu. A taj je da se pri tim situacijama razvija stanje OKSIDATIVNOG STRESA!!

A, šta je to?

Oksidativni stres

Oksidativni stres je trenutno glavni uzrok oštećenja i smrti ljudskog organizma, ukoliko se izuzmu teške fizičke povrede i izrazite genetske malformacije!

Oksidativni stres nastaje u organizmu kada se pod dejstvom spoljašnjih (egzogenih) ili unutrašnjih (endogenih) faktora pokrene prekomerno oslobađanje slobodnih radikala – reaktivnih vrsta kiseonika (ROS – superoksid, peroksid, hidroksilni radikal, oksibenzon, hipohlorne molekule) i reaktivnih vrsta azota (RNS – azot monoksid, peroksinitrit). Ukoliko organizam ne uspe da ih izreguliše putem različitih kontrolnih mehanizama (preuzimanje, dismutacija, reparacija i dr.), ovakvi slobodni radikali izazivaju snažne reakcije i razaranja na nivou membrana, organela (lizizomi, meitohondrije, peroksizom) i jezgra ćelija, delujući na strukturu proteina, izazivajući i lipidnu perioksidaciju i oštećenja DNK! Ukoliko ovakvo patofiziološki stanje na nivou ćelija i tkiva organa potraje, dalje dolazi do razvoja širokog spektra poremećaja, bolesti i smrti.

Tako, neregulisani oksidativni stres razara zidove krvnih sudova i mišić srca, dovodeći do kardiovaskularnih bolesti – ateroskleroze, koronarne bolesti, hipertenzije, infarkta i dr. Spisak drugih bolesti koje nastaju produženim dejstvom oksidativnog stresa je skoro nepregledan: metabolički sindrom (hiperkortizolemija, hiperlipidemija, insulin rezistencija, zamašćenje unutrašnjih organa itd); diabetes tip 2 (više od 90 procenata dijabetičara strada od ove forme!?); oštećenja bubrega (tubula, fibroze i dr.); plućne bolesti (astma, opstruktivni bronhitis i dr.); hronične upale (konstantnim stimulacijom lučenja proinflamatornih citokina: IL-1b, TNFa, IL-6, il-19); autoimune bolesti (reumatodini artritis i dr.);  GIT – hronične upale creva (iritabilni i krvavi kolitis), oštećenja sluznice želuca, poremećaji funkcije i tkiva jetre i dr.; neurodegenerativne bolesti – Alchajmerova bolest, Parkinsonova bolest, makularna degeneracija i dr.; katarakta; ćelijske mutacije – mutageneza, karcinogeneza (maligniteti) i ubrzano starenje itd. itd…

Vratimo se sada smislu navođenja prethodnih podataka. Na početku ovog poglavlja naveo sam da uzročnici razvoja oksidativnog stresa mogu biti spoljašnji (egzogeni) i unutrašnji (endogeni). U spoljašnje spadaju radioaktivna zračenja, ultraljubičasto zračenje, toksini iz okolinskog zagađenja (teški metali, smog, duvanski dim, ugljen monoksid, azotni oksidi, benzen, hlor, ozon, formaldehid, rastvarači, boje, pesticidi, parfemi, lekovi, kozmetika, prerađevine hrane sa veštačkim aditivima, trans masti, lipidni peroksidi u mastima i dr.), hipoksija, hiperoksija, težak fizički napor i dr.

Unutrašnji (endogeni) faktori oksidativnog stresa se pojavljuju nakon razvoja snažnih unutrašnjih emocionalnih doživljaja i izrazitog psihosomatskog (vegetativnog) preživljavanja određenih spoljašnjih situacija u kojima se nalazi zatečena individua. Situacije u kojima je dokazano da se kao posledica takvog tipa preživljavanja razvija oksidativni stres na organskom nivou su psihičke traume, teži i dugotrajniji životni stresovi (SLS – serious life stress) i isrpljenje kapaciteta adaptacije – sindrom pregorevanja. I gle čuda, u ovom spektru je dokazano važno mesto koje zauzima faktor društvene izolacije!!

Socijalna distanca – zašto?

Vidimo sada da je termin „socijalna distanca“ pažljivo odabran, od strane majstora, u sklopu kampanje „Covid 19“. Iako to na početku nije bilo jasno i još uvek nije jasno mnogima zbog čega nije adekvatno zamenjen terminom „fizička distanca“. Socijalna distanca u sebi integriše izolacioni sa imobilizacionim stresom, u sprezi sa „lock down“ – om, odnosno zaključavanjem. U sprezi sa svakodnevnim zastrašivanjem (o psihodinamici, cilju i efektima medijskog i javnog nametanja svakodnevnog straha najvišeg intenziteta u sklopu ovog projekta – u nekom sledećem tekstu), a u vremenu koje beskrajno teče u ovakvom ambijentu, izuzetno je teško prosečnom čoveku današnjice izbeći dolazak u stanje doživljaja koje zatim „po službenoj dužnosti“ pokreće razvoj oksidativnog stresa u njegovom organizmu.

Tako dolazimo do tačke magičnog obrta koji trenutno proizvode dominantni alhemičari i primenjuju ga na svetsku populaciju koja zavisi od njih. Nematerijalnim putem proizvode materijalne posledice! Na ovo bi fizičari, uobičajene sveznalice, rekli: naravno, to je dokaz privremene transformacije energije u materiju, da bi se nakon alhemičarskog razaranja tela koje je poseduje vratila u slobodnu formu!?

Oksidativni stres i duhovna sloboda

Šta je, pa sad, to? I šta je ovome koji je to napisao?

Ostavljam mogućnost tumačenja uz nadrealna razmišljanja… Ukoliko je uopšte ostalo nešto od takvog potencijala u mozgu?

www.zvokodzokic.com

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